Operant behavior to obtain palatable food modifies neuronal plasticity in the brain reward circuit

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MedWorm: Binge Eating Disorder
Operant behavior to obtain palatable food modifies neuronal plasticity in the brain reward circuit
Abstract: Palatability enhances food intake by hedonic mechanisms that prevail over caloric necessities. Different studies have demonstrated the role of endogenous cannabinoids in the mesocorticolimbic system in controlling food hedonic value and consumption. We hypothesize that the endogenous cannabinoid system could also be involved in the development of food-induced behavioral alterations, such as food-seeking and binge-eating, by a mechanism that requires neuroplastic changes in the brain reward pathway. For this purpose, we evaluated the role of the CB1 cannabinoid receptor (CB1-R) in the behavioral and neuroplastic changes induced by operant training for standard, highly caloric or highly palatable isocaloric food using different genetics, viral and pharmacological approaches. Neurop…

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Boise Bipolar Center, Charles K. Bunch, Ph.D, Boise Idaho Therapist Mental health photo 2168_zps680c452f.jpg

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